Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons

Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent, potentially irreversible adverse effect of cytotoxic chemotherapy often leading to a reduction or discontinuation of treatment which negatively impacts patients' prognosis. To date, however, neither predictive biomarkers nor preve...

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Bibliographic Details
Main Authors: Christian Schinke, Valeria Fernandez Vallone, Andranik Ivanov, Yangfan Peng, Péter Körtvelyessy, Luca Nolte, Petra Huehnchen, Dieter Beule, Harald Stachelscheid, Wolfgang Boehmerle, Matthias Endres
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Induced pluripotent stem cell derived sensory neurons (iPSC-DSN)
Chemotherapy induced neuropathy
3R
Replacement
Transcriptome
Lithium
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001406

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http://www.sciencedirect.com/science/article/pii/S0969996121001406

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