Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages

Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages

Abstract Background Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). We tested whether the induction of dNTP pool imbala...

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Bibliographic Details
Main Authors: Caitlin Shepard, Joella Xu, Jessica Holler, Dong-Hyun Kim, Louis M. Mansky, Raymond F. Schinazi, Baek Kim
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Retrovirology
Subjects:
HIV-1
Reverse transcription
SAMHD1
dNTP pool imbalance
Mutagenesis
Macrophages
Online Access:http://link.springer.com/article/10.1186/s12977-019-0491-0

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http://link.springer.com/article/10.1186/s12977-019-0491-0

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