A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction

Methods for eQTL mapping from total and allele-specific gene expression typically are too computationally heavy to apply to large scale studies. Here, the authors describe a computationally efficient method to identify eQTLs, fine-map and predict expression from total and allele-specific gene expres...

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Bibliographic Details
Main Authors: Yanyu Liang, François Aguet, Alvaro N. Barbeira, Kristin Ardlie, Hae Kyung Im
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21592-8