Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150Glued and TDP-43 is largely unknown. Here, we report t...

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Bibliographic Details
Main Authors: Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:EBioMedicine
Subjects:
Dynactin
TDP-43
Axonal transport
Dopamine
Parkinsonian syndrome
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641730230X

Internet

http://www.sciencedirect.com/science/article/pii/S235239641730230X

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