Systematic evaluation of cancer‐specific genetic risk score for 11 types of cancer in The Cancer Genome Atlas and Electronic Medical Records and Genomics cohorts

Systematic evaluation of cancer‐specific genetic risk score for 11 types of cancer in The Cancer Genome Atlas and Electronic Medical Records and Genomics cohorts

Abstract Background Genetic risk score (GRS) is an odds ratio (OR)‐weighted and population‐standardized method for measuring cumulative effect of multiple risk‐associated single nucleotide polymorphisms (SNPs). We hypothesize that GRS is a valid tool for risk assessment of most common cancers. Metho...

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Bibliographic Details
Main Authors: Zhuqing Shi, Hongjie Yu, Yishuo Wu, Xiaoling Lin, Quanwa Bao, Haifei Jia, Chelsea Perschon, David Duggan, Brian T. Helfand, Siqun L. Zheng, Jianfeng Xu
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Cancer Medicine
Subjects:
age at diagnosis
cancer
genetic risk score
Online Access:https://doi.org/10.1002/cam4.2143

Internet

https://doi.org/10.1002/cam4.2143

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