A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome

Background: Lynch syndrome (LS) is an inherited autosomal dominant disorder characterised by an increased risk of colorectal cancer (CRC) and other cancers, and caused by mutations in the deoxyribonucleic acid (DNA) mismatch repair genes. Objective: To evaluate the accuracy and cost-effectiveness of...

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Bibliographic Details
Main Authors: Tristan Snowsill, Nicola Huxley, Martin Hoyle, Tracey Jones-Hughes, Helen Coelho, Chris Cooper, Ian Frayling, Chris Hyde
Format: Article
Language:English
Published: NIHR Journals Library 2014-09-01
Series:Health Technology Assessment
Online Access:https://doi.org/10.3310/hta18580