BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Summary: The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction...

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Bibliographic Details
Main Authors: Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri A. Diavatopoulos, Triantafyllos Chavakis, Mihai G. Netea
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
innate immune memory
trained immunity
neutrophil
polymorphonuclear leukocytes
BCG
nonspecific effects of vaccines
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313760

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http://www.sciencedirect.com/science/article/pii/S2211124720313760

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