CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease

CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease

Abstract Background The presynaptic protein neuregulin1 (NRG1) is cleaved by beta-site APP cleaving enzyme 1 (BACE1) in a similar way as amyloid precursor protein (APP) NRG1 can activate post-synaptic receptor tyrosine-protein kinase erbB4 (ErbB4) and was linked to schizophrenia. The NRG1/ErbB4 comp...

Full description

Bibliographic Details
Main Authors: François Mouton-Liger, Julien Dumurgier, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Hugo Vanderstichele, Eugeen Vanmechelen, Elodie Bouaziz-Amar, Kaj Blennow, Jacques Hugon, Claire Paquet
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
NRG1
Aβ
BACE1
CSF
Biomarkers
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13195-020-00655-w

Internet

http://link.springer.com/article/10.1186/s13195-020-00655-w

Similar Items