Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis

Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis

Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. Identification of multiple covalent cytosine modifications raises the question of how these derivatized bases influence stem cell commitment. Using a replicative...

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Bibliographic Details
Main Authors: Jozef Madzo, Hui Liu, Alexis Rodriguez, Aparna Vasanthakumar, Sriram Sundaravel, Donne Bennett D. Caces, Timothy J. Looney, Li Zhang, Janet B. Lepore, Trisha Macrae, Robert Duszynski, Alan H. Shih, Chun-Xiao Song, Miao Yu, Yiting Yu, Robert Grossman, Brigitte Raumann, Amit Verma, Chuan He, Ross L. Levine, Don Lavelle, Bruce T. Lahn, Amittha Wickrema, Lucy A. Godley
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713007286

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http://www.sciencedirect.com/science/article/pii/S2211124713007286

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