Natural killer T cells in advanced melanoma patients treated with tremelimumab.

Natural killer T cells in advanced melanoma patients treated with tremelimumab.

A significant barrier to effective immune clearance of cancer is loss of antitumor cytotoxic T cell activity. Antibodies to block pro-apoptotic/downmodulatory signals to T cells are currently being tested. Because invariant natural killer T cells (iNKT) can regulate the balance of Th1/Th2 cellular i...

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Bibliographic Details
Main Authors: F Javier Ibarrondo, Otto O Yang, Thinle Chodon, Earl Avramis, Yohan Lee, Hooman Sazegar, Jason Jalil, Bartosz Chmielowski, Richard C Koya, Ingrid Schmid, Jesus Gomez-Navarro, Beth D Jamieson, Antoni Ribas, Begoña Comin-Anduix
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805549?pdf=render

Internet

http://europepmc.org/articles/PMC3805549?pdf=render

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