The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner

The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner

HERC E3 subfamily members are parts of the E3 ubiquitin ligases and key players for a wide range of cellular functions. Though the involvement of the Ubiquitin Proteasome System in blood disorders has been broadly studied, so far the role of large HERCs in this context remains unexplored. In the pre...

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Bibliographic Details
Main Authors: Muhammad Shahzad Ali, Cristina Panuzzo, Chiara Calabrese, Alessandro Maglione, Rocco Piazza, Daniela Cilloni, Giuseppe Saglio, Barbara Pergolizzi, Enrico Bracco
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
E3 ubiquitin ligases
ubiquitin proteasome system
myeloid neoplasms
<i>Bcr-Abl1</i>
<i>HERC1</i>
gene expression
Online Access:https://www.mdpi.com/2072-6694/13/2/341

Internet

https://www.mdpi.com/2072-6694/13/2/341

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