KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors

Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands. Directly impacting NK cell function, KIR polymorphism associates with infectio...

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Bibliographic Details
Main Authors: Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Paul J. Norman
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
NK cells
KIR
HLA class I
Iranian populations
immune diversity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00556/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00556/full

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