Neurofilament light and heterogeneity of disease progression in amyotrophic lateral sclerosis: development and validation of a prediction model to improve interventional trials

Neurofilament light and heterogeneity of disease progression in amyotrophic lateral sclerosis: development and validation of a prediction model to improve interventional trials

Abstract Background Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light chains (NfL) could be used to anticipate disease progression and increase trial power. Met...

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Bibliographic Details
Main Authors: Simon Witzel, Felix Frauhammer, Petra Steinacker, David Devos, Pierre-François Pradat, Vincent Meininger, Steffen Halbgebauer, Patrick Oeckl, Joachim Schuster, Simon Anders, Johannes Dorst, Markus Otto, Albert C. Ludolph
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Translational Neurodegeneration
Subjects:
Neurofilament light
Prediction model
Disease progression
Amyotrophic lateral sclerosis
Interventional trials
Statistical power
Online Access:https://doi.org/10.1186/s40035-021-00257-y

Internet

https://doi.org/10.1186/s40035-021-00257-y

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