Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line

Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line

Memantine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, and is an approved drug for the treatment of moderate-to-severe Alzheimer’s disease. We identified a mouse strain with a naturally occurring mutation and an ataxic phenotype that presents with severe leg cramps. T...

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Bibliographic Details
Main Authors: Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Hiroyuki Takahashi, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Kenji Mizuguchi, Taisei Nomura, Junichiro Matsuda, Toshihide Tabata, Hiroshi Takemori
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Genes
Subjects:
GRID2
GluRδ2
memantine
NMDA receptor
cerebellum
Online Access:http://www.mdpi.com/2073-4425/5/4/1095

Internet

http://www.mdpi.com/2073-4425/5/4/1095

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