Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line
Memantine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, and is an approved drug for the treatment of moderate-to-severe Alzheimer’s disease. We identified a mouse strain with a naturally occurring mutation and an ataxic phenotype that presents with severe leg cramps. T...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2014-12-01
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Series: | Genes |
Subjects: | |
Online Access: | http://www.mdpi.com/2073-4425/5/4/1095 |