Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-β Response in HTLV-1-Associated Neuroinflammation

Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-β Response in HTLV-1-Associated Neuroinflammation

HTLV-1-Associated Myelopathy (HAM/TSP) is a progressive neuroinflammatory disorder for which no disease-modifying treatment exists. Modest clinical benefit from type I interferons (IFN-α/β) in HAM/TSP contrasts with its recently identified IFN-inducible gene signature. In addition, IFN-α treatment i...

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Bibliographic Details
Main Authors: Fabio E. Leal, Soraya Maria Menezes, Emanuela A. S. Costa, Phillip M. Brailey, Lucio Gama, Aluisio C. Segurado, Esper G. Kallas, Douglas F. Nixon, Tim Dierckx, Ricardo Khouri, Jurgen Vercauteren, Bernardo Galvão-Castro, Rui Andre Saraiva Raposo, Johan Van Weyenbergh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
HTLV-1
HIV
retrovirus
evolution
interferon
neuroinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.00985/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.00985/full

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