Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter

Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter

The efficacy of anti-cancer drugs in patients can be attenuated by the development of multi-drug resistance (MDR) due to ATP-binding cassette (ABC) transporters overexpression. In this in vitro study, we determined the reversal efficacy of the epidermal growth factor receptor (EFGR) inhibitor, sapti...

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Bibliographic Details
Main Authors: Hai-Ling Gao, Pranav Gupta, Qingbin Cui, Yunali V. Ashar, Zhuo-Xun Wu, Leli Zeng, Zi-Ning Lei, Qiu-Xu Teng, Charles R. Ashby, Yingjun Guan, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
sapitinib
ABCB1
drug resistance
reversal
colon cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.574861/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.574861/full

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