Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells

Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells

Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and immune-mediated neurotoxicity, but the molecular mechanisms of αSynAgg-induced immune activation are poorly defined. We performed quantitative prote...

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Bibliographic Details
Main Authors: Souvarish Sarkar, Eric B. Dammer, Emir Malovic, Abby L. Olsen, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Danielle L. Oliver, Duc Duong, Valerie Joers, Nicholas Seyfried, Meixiang Huang, Thomas Kukar, Malú G. Tansey, Anumantha G. Kanthasamy, Srikant Rangaraju
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
synuclein
microglia
neuroinflammation
Parkinson's disease
proteomics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00033/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00033/full

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