Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.

Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection and all vaccine candidates tested to date. To inves...

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Bibliographic Details
Main Authors: Rami Sommerstein, Lukas Flatz, Melissa M Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan Ter Meulen, Dorothée Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D Pinschewer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005276

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https://doi.org/10.1371/journal.ppat.1005276

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