Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats

Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats

ObjectiveIL-17A plays a major role in the pathogenesis of spondyloarthritis (SpA). Here we assessed the impact of inhibition of RAR related orphan receptor-γ (RORC), the key transcription factor controlling IL-17 production, on experimental SpA in HLA-B27 transgenic (tg) rats.MethodsExperimental SpA...

Full description

Bibliographic Details
Main Authors:	Melissa N. van Tok, Mohamed Mandour, Joseph Wahle, Mark E. Labadia, Marleen G. H. van de Sande, Gerald Nabozny, Dominique L. Baeten, Leonie M. van Duivenvoorde
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Immunology
Subjects:	spondyloarthritis IL-17A RORC IL-22 HLA-B27 transgenic rats
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.699987/full

Similar Items

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling
by: Melissa N. van Tok, et al.
Published: (2018-07-01)

The Role of the IL-23/IL-17 Axis in Disease Initiation in Spondyloarthritis: Lessons Learned From Animal Models
by: Mohamed Mandour, et al.
Published: (2021-06-01)

Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats
by: Melissa N. van Tok, et al.
Published: (2017-08-01)

mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo
by: Sijia Chen, et al.
Published: (2020-02-01)

Positive and Negative Regulation of Th17 Cell Differentiation: Evaluating The Impact of RORC2
by: Mazdak Ganjalikhani Hakemi, et al.
Published: (2014-04-01)

Regulation of RORC2 expression during human CD4+T cell differentiation
by: Yahia, Hanane
Published: (2017)

Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort
by: Janneke J. de Winter, et al.
Published: (2018-03-01)

Innate Cells: The Alternative Source of IL-17 in Axial and Peripheral Spondyloarthritis?
by: Nicolas Rosine, et al.
Published: (2021-01-01)

RORC2 Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis
by: Agnieszka Paradowska-Gorycka, et al.
Published: (2016-04-01)

Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women
by: Zhe Xie, et al.
Published: (2018-06-01)

Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection
by: Chengappa G. Kavadichanda, et al.
Published: (2021-03-01)

Relative overexpression of membrane-bound versus soluble TNF in spondyloarthritis
by: Ambarus Carmen A, et al.
Published: (2012-11-01)

The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis
by: Tue W. Kragstrup, et al.
Published: (2018-09-01)

Anti-IL-17 Agents in the Treatment of Axial Spondyloarthritis
by: Atzeni F, et al.
Published: (2021-05-01)

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1
by: Cynthia M. Fehres, et al.
Published: (2019-06-01)

Patients’ and rheumatologists’ perceptions on preventive intervention in rheumatoid arthritis and axial spondyloarthritis
by: Laurette van Boheemen, et al.
Published: (2020-09-01)

Effects of a low-dose IL-2 treatment in HLA-B27 transgenic rat model of spondyloarthritis
by: L. M. Araujo, et al.
Published: (2021-07-01)

Spondyloarthritis in India
by: Anand N Malaviya
Published: (2020-01-01)

Promising Treatment Options for Axial Spondyloarthritis: An Overview of Experimental Pharmacological Agents
by: Tahir H, et al.
Published: (2021-07-01)

From Science to Success? Targeting Tyrosine Kinase 2 in Spondyloarthritis and Related Chronic Inflammatory Diseases
by: Dominika Hromadová, et al.
Published: (2021-07-01)

Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue
by: Oliwia Rysnik, et al.
Published: (2016-12-01)

Are gender-specific approaches needed in diagnosing early axial spondyloarthritis? Data from the SPondyloArthritis Caught Early cohort
by: Augusta Ortolan, et al.
Published: (2018-10-01)

A single determination of C-reactive protein does not suffice to declare a patient with a diagnosis of axial spondyloarthritis ‘CRP-negative’
by: Robert Landewé, et al.
Published: (2018-09-01)

Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots
by: Giulia Furesi, et al.
Published: (2021-06-01)

Functional Differences Between Human NKp44— and NKp44+ RORC+ Innate Lymphoid Cells
by: Kerim eHoorweg, et al.
Published: (2012-04-01)

Incidence of anterior uveitis in patients with axial spondyloarthritis treated with anti-TNF or anti-IL17A: a systematic review, a pairwise and network meta-analysis of randomized controlled trials
by: Damien Roche, et al.
Published: (2021-07-01)

Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23
by: Yuhai Chen, et al.
Published: (2018-11-01)

ON THE TERMINOLOGY OF SPONDYLOARTHRITIS
by: Sh. F. Erdes, et al.
Published: (2016-02-01)

Effects of IL-6 Signaling Pathway Inhibition on Weight and BMI: A Systematic Review and Meta-Analysis
by: Olivia Patsalos, et al.
Published: (2020-08-01)

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses
by: Silvia Menegatti, et al.
Published: (2019-03-01)

IL-23 Inhibition in Ankylosing Spondylitis: Where Did It Go Wrong?
by: Dominique Baeten, et al.
Published: (2021-02-01)

The performance of different classification criteria sets for spondyloarthritis in the worldwide ASAS-COMOSPA study
by: Pauline Bakker, et al.
Published: (2017-05-01)

A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis
by: Jacqueline E. Paramarta, et al.
Published: (2016-10-01)

GPs’ patterns of clinical assessment when faced with a patient suspected for spondyloarthritis: a prospective educational intervention study
by: Marloes van Onna, et al.
Published: (2017-01-01)

IL-17A and TNF Modulate Normal Human Spinal Entheseal Bone and Soft Tissue Mesenchymal Stem Cell Osteogenesis, Adipogenesis, and Stromal Function
by: Tobias Russell, et al.
Published: (2021-02-01)

Spectrum of spondyloarthritis
by: Himanshu Pathak, et al.
Published: (2020-01-01)

An Italian Disease-Based Registry of Axial and Peripheral Spondyloarthritis: The SIRENA Study
by: Alen Zabotti, et al.
Published: (2021-09-01)

Ankylosing spondylitis and non-radiographic axial spondyloarthritis: Two stages of disease?
by: D G Rumyantseva, et al.
Published: (2017-05-01)

Spondyloarthritis: modern terminology and definitions
by: Sh F Erdes, et al.
Published: (2019-05-01)

Eighth International Congress on Spondyloarthritis
by: Anna Georgiyevna Bochkova
Published: (2013-03-01)