Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment.

Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment.

Cancer cells can live and grow if they succeed in creating a favorable niche that often includes elements from the immune system. While T lymphocytes play an important role in the host response to tumor growth, the mechanism of their trafficking to the tumor remains poorly understood. We show here t...

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Bibliographic Details
Main Authors: Vita S Salsman, Kevin K H Chow, Donald R Shaffer, Huseyin Kadikoy, Xiao-Nan Li, Claudia Gerken, Laszlo Perlaky, Leonid S Metelitsa, Xiuhua Gao, Meena Bhattacharjee, Karen Hirschi, Helen E Heslop, Stephen Gottschalk, Nabil Ahmed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3103535?pdf=render

Internet

http://europepmc.org/articles/PMC3103535?pdf=render

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