Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment.
Cancer cells can live and grow if they succeed in creating a favorable niche that often includes elements from the immune system. While T lymphocytes play an important role in the host response to tumor growth, the mechanism of their trafficking to the tumor remains poorly understood. We show here t...
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doaj-8934db56267140b5836fc475bb10fb932020-11-25T01:35:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0165e2026710.1371/journal.pone.0020267Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment.Vita S SalsmanKevin K H ChowDonald R ShafferHuseyin KadikoyXiao-Nan LiClaudia GerkenLaszlo PerlakyLeonid S MetelitsaXiuhua GaoMeena BhattacharjeeKaren HirschiHelen E HeslopStephen GottschalkNabil AhmedCancer cells can live and grow if they succeed in creating a favorable niche that often includes elements from the immune system. While T lymphocytes play an important role in the host response to tumor growth, the mechanism of their trafficking to the tumor remains poorly understood. We show here that T lymphocytes consistently infiltrate the primary brain cancer, medulloblastoma. We demonstrate, both in vitro and in vivo, that these T lymphocytes are attracted to tumor deposits only after the tumor cells have interacted with tumor vascular endothelium. Macrophage Migration Inhibitory Factor (MIF)" is the key chemokine molecule secreted by tumor cells which induces the tumor vascular endothelial cells to secrete the potent T lymphocyte attractant "Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES)." This in turn creates a chemotactic gradient for RANTES-receptor bearing T lymphocytes. Manipulation of this pathway could have important therapeutic implications.http://europepmc.org/articles/PMC3103535?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vita S Salsman Kevin K H Chow Donald R Shaffer Huseyin Kadikoy Xiao-Nan Li Claudia Gerken Laszlo Perlaky Leonid S Metelitsa Xiuhua Gao Meena Bhattacharjee Karen Hirschi Helen E Heslop Stephen Gottschalk Nabil Ahmed |
spellingShingle |
Vita S Salsman Kevin K H Chow Donald R Shaffer Huseyin Kadikoy Xiao-Nan Li Claudia Gerken Laszlo Perlaky Leonid S Metelitsa Xiuhua Gao Meena Bhattacharjee Karen Hirschi Helen E Heslop Stephen Gottschalk Nabil Ahmed Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. PLoS ONE |
author_facet |
Vita S Salsman Kevin K H Chow Donald R Shaffer Huseyin Kadikoy Xiao-Nan Li Claudia Gerken Laszlo Perlaky Leonid S Metelitsa Xiuhua Gao Meena Bhattacharjee Karen Hirschi Helen E Heslop Stephen Gottschalk Nabil Ahmed |
author_sort |
Vita S Salsman |
title |
Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. |
title_short |
Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. |
title_full |
Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. |
title_fullStr |
Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. |
title_full_unstemmed |
Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. |
title_sort |
crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting t lymphocytes to the tumor microenvironment. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Cancer cells can live and grow if they succeed in creating a favorable niche that often includes elements from the immune system. While T lymphocytes play an important role in the host response to tumor growth, the mechanism of their trafficking to the tumor remains poorly understood. We show here that T lymphocytes consistently infiltrate the primary brain cancer, medulloblastoma. We demonstrate, both in vitro and in vivo, that these T lymphocytes are attracted to tumor deposits only after the tumor cells have interacted with tumor vascular endothelium. Macrophage Migration Inhibitory Factor (MIF)" is the key chemokine molecule secreted by tumor cells which induces the tumor vascular endothelial cells to secrete the potent T lymphocyte attractant "Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES)." This in turn creates a chemotactic gradient for RANTES-receptor bearing T lymphocytes. Manipulation of this pathway could have important therapeutic implications. |
url |
http://europepmc.org/articles/PMC3103535?pdf=render |
work_keys_str_mv |
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