Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal AdenocarcinomasSummary

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal AdenocarcinomasSummary

Background & Aims: Colorectal cancer is an epigenetically heterogeneous disease, however, the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear. Methods: Genome-scale methylation and transcript expression were measured by DNA Methylation and RNA expression microarray...

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Bibliographic Details
Main Authors: Lochlan Fennell, Troy Dumenil, Leesa Wockner, Gunter Hartel, Katia Nones, Catherine Bond, Jennifer Borowsky, Cheng Liu, Diane McKeone, Lisa Bowdler, Grant Montgomery, Kerenaftali Klein, Isabell Hoffmann, Ann-Marie Patch, Stephen Kazakoff, John Pearson, Nicola Waddell, Pratyaksha Wirapati, Paul Lochhead, Yu Imamura, Shuji Ogino, Renfu Shao, Sabine Tejpar, Barbara Leggett, Vicki Whitehall
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X19300414

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http://www.sciencedirect.com/science/article/pii/S2352345X19300414

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