Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain

According to the network model of neurodegeneration, the spread of pathogenic proteins occurs selectively along connected brain regions. We tested in vivo whether the distribution of filamentous tau (measured with [18F]flortaucipir-PET), fibrillar amyloid-β ([11C]PIB-PET) and glucose hypometabolism...

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Bibliographic Details
Main Authors: Rik Ossenkoppele, Leonardo Iaccarino, Daniel R. Schonhaut, Jesse A. Brown, Renaud La Joie, James P. O'Neil, Mustafa Janabi, Suzanne L. Baker, Joel H. Kramer, Maria-Luisa Gorno-Tempini, Bruce L. Miller, Howard J. Rosen, William W. Seeley, William J. Jagust, Gil D. Rabinovici
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158219301986

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http://www.sciencedirect.com/science/article/pii/S2213158219301986

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