Mutational and Combinatorial Control of Self-Assembling and Disassembling of Human Proteasome α Subunits

Mutational and Combinatorial Control of Self-Assembling and Disassembling of Human Proteasome α Subunits

Eukaryotic proteasomes harbor heteroheptameric α-rings, each composed of seven different but homologous subunits α1−α7, which are correctly assembled via interactions with assembly chaperones. The human proteasome α7 subunit is reportedly spontaneously a...

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Bibliographic Details
Main Authors: Taichiro Sekiguchi, Tadashi Satoh, Eiji Kurimoto, Chihong Song, Toshiya Kozai, Hiroki Watanabe, Kentaro Ishii, Hirokazu Yagi, Saeko Yanaka, Susumu Uchiyama, Takayuki Uchihashi, Kazuyoshi Murata, Koichi Kato
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
proteasome
self-assembly
homo-oligomer
hetero-oligomer
size exclusion chromatography
native mass spectrometry
crystal structure
atomic force microscopy
electron microscopy
Online Access:https://www.mdpi.com/1422-0067/20/9/2308

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https://www.mdpi.com/1422-0067/20/9/2308

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