Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

Abstract Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD). Recently, more than fifty other lysosomal storage disorder gene variants have been identified i...

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Bibliographic Details
Main Authors: Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Neurodegeneration
Subjects:
Ageing
Glycosphingolipid
Ganglioside
Glucocerebrosidase
Lysosome
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-019-0339-z

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http://link.springer.com/article/10.1186/s13024-019-0339-z

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