DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint factors (DDCF) and DNA damage repair fa...

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Bibliographic Details
Main Authors: Huihong Zeng, Gayani K. Nanayakkara, Ying Shao, Hangfei Fu, Yu Sun, Ramon Cueto, William Y. Yang, Qian Yang, Haitao Sheng, Na Wu, Luqiao Wang, Wuping Yang, Hongping Chen, Lijian Shao, Jianxin Sun, Xuebin Qin, Joon Y. Park, Konstantinos Drosatos, Eric T. Choi, Qingxian Zhu, Hong Wang, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
DNA damage checkpoint and repair factors
inflammation
cancers
genomic instability
danger associated molecular patterns (DAMPs)
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00516/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00516/full

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