The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease

The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease

Genetic studies identified mutations in several immune-related genes that confer increased risk for developing Alzheimer's disease (AD), suggesting a key role for microglia in AD pathology. Microglia are recruited to and actively modulate the local toxicity of amyloid plaques in models of AD th...

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Bibliographic Details
Main Authors: Victoria E. von Saucken, Taylor R. Jay, Gary E. Landreth
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Amyloid accumulation
Phagocytosis
Neurites
Triggering receptor expressed on myeloid cells 2
Pre-plaque
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303478

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http://www.sciencedirect.com/science/article/pii/S0969996120303478

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