T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-redirected T-cells target intracellular antigens, mar...

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Bibliographic Details
Main Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
acute myeloid leukemia (aml)
t-cell immunotherapy
hematopoietic stem cells
op9-dl1
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1727078

Internet

http://dx.doi.org/10.1080/2162402X.2020.1727078

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