Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages[S]

Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages[S]

An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester hydrolase 1 (Nceh1) and hormon...

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Bibliographic Details
Main Authors: Motohiro Sekiya, Daisuke Yamamuro, Taichi Ohshiro, Akira Honda, Manabu Takahashi, Masayoshi Kumagai, Kent Sakai, Shuichi Nagashima, Hiroshi Tomoda, Masaki Igarashi, Hiroaki Okazaki, Hiroaki Yagyu, Jun-ichi Osuga, Shun Ishibashi
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Journal of Lipid Research
Subjects:
KIAA1363
arylacetamide deacetylase-like 1
atherosclerosis
foam cells
acyl-CoA:cholesterol acyltransferase
lipase/hormone-sensitive lipase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350124

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http://www.sciencedirect.com/science/article/pii/S0022227520350124

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