Rapid Mutation Scanning of Genes Associated with Familial Cancer Syndromes Using Denaturing High-Performance Liquid Chromatography

Rapid Mutation Scanning of Genes Associated with Familial Cancer Syndromes Using Denaturing High-Performance Liquid Chromatography

Germline mutations in tumor suppressor genes, or less frequently oncogenes, have been identified in up to 19 familial cancer syndromes including Li-Fraumeni syndrome, familial paraganglioma, familial adenomatous polyposis coli and breast and ovarian cancers. Multiple genes have been associated with...

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Bibliographic Details
Main Authors: Deborah J. Marsh, George Theodosopoulos, Viive Howell, Anne-Louise Richardson, Diana E. Benn, Anné L. Proos, Charis Eng, Bruce G. Robinson
Format: Article
Language:English
Published: Elsevier 2001-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
dHPLC
mutation detection
PTEN
RET
VHL
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558601800476

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http://www.sciencedirect.com/science/article/pii/S1476558601800476

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