Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells

Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells

Zika virus (ZIKV), an emerging flavivirus that causes neurodevelopmental impairment to fetuses and has been linked to Guillain-Barré syndrome continues to threaten global health due to the absence of targeted prophylaxis or treatment. Nucleoside analogues are good examples of efficient anti...

Full description

Bibliographic Details
Main Authors: Jean A. Bernatchez, Michael Coste, Sungjun Beck, Grace A. Wells, Lucas A. Luna, Alex E. Clark, Zhe Zhu, David Hecht, Jeremy N. Rich, Christal D. Sohl, Byron W. Purse, Jair L. Siqueira-Neto
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Viruses
Subjects:
Zika virus
nucleoside analogues
antiviral agents
NS5
prodrugs
ProTides
neural stem cells
RNA-dependent RNA polymerase
Online Access:https://www.mdpi.com/1999-4915/11/4/365

Internet

https://www.mdpi.com/1999-4915/11/4/365

Similar Items