Structural and functional perturbation of Giardia lamblia triosephosphate isomerase by modification of a non-catalytic, non-conserved region.

Structural and functional perturbation of Giardia lamblia triosephosphate isomerase by modification of a non-catalytic, non-conserved region.

BACKGROUND: We have previously proposed triosephosphate isomerase of Giardia lamblia (GlTIM) as a target for rational drug design against giardiasis, one of the most common parasitic infections in humans. Since the enzyme exists in the parasite and the host, selective inhibition is a major challenge...

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Bibliographic Details
Main Authors: Gloria Hernández-Alcántara, Alfredo Torres-Larios, Sergio Enríquez-Flores, Itzhel García-Torres, Adriana Castillo-Villanueva, Sara T Méndez, Ignacio de la Mora-de la Mora, Saúl Gómez-Manzo, Angélica Torres-Arroyo, Gabriel López-Velázquez, Horacio Reyes-Vivas, Jesús Oria-Hernández
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3718800?pdf=render

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http://europepmc.org/articles/PMC3718800?pdf=render

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