Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species

Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species

Positron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. Previous studies suggested similar pons and white-matter uptake in Alzheime...

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Bibliographic Details
Main Authors: Francisco Oliveira, Antoine Leuzy, João Castelhano, Konstantinos Chiotis, Steen Gregers Hasselbalch, Juha Rinne, Alexandre Mendonça, Markus Otto, Alberto Lleó, Isabel Santana, Jarkko Johansson, Sarah Anderl-Straub, Christine Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Herukka Sanna-Kaisa, Erik Portelius, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Ana P. Moreira, Antero Abrunhosa, Agneta Nordberg, Miguel Castelo-Branco
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S221315821830264X

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http://www.sciencedirect.com/science/article/pii/S221315821830264X

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