Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells

Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells

A series of novel C4-C7-tethered biscoumarin derivatives (<b>12a</b>–<b>e</b>) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin <b>12d</b> was found to be the most effective inhibitor of both a...

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Bibliographic Details
Main Authors: Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnatova, Tomáš Kučera, Petr Bzonek, Nikola Novakova, Daniel Jun, Lucie Junova, Jan Korábečný, Kamil Kuča, Mária Kožurková
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
biscoumarin
Alzheimer’s disease
blood–brain barrier
cholinesterase
antiproliferative activity
A549
Online Access:https://www.mdpi.com/1422-0067/22/8/3830

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https://www.mdpi.com/1422-0067/22/8/3830

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