Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway

Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway

Activation of Akt by insulin is transmitted via phosphatidylinositol-3-OH kinase (PI-3K) and enhances glucose uptake. The PI-3K/Akt signaling is diminished in insulin resistance. Thus, approaches that activate PI-3K/Akt signaling leading to improved glucose uptake may ameliorate hyperglycemia. Here...

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Bibliographic Details
Main Authors: Shuichiro Yano, Saori Morino-Koga, Tatsuya Kondo, Mary Ann Suico, Tomoaki Koga, Yuichiro Shimauchi, Shingo Matsuyama, Tsuyoshi Shuto, Takashi Sato, Eiichi Araki, Hirofumi Kai
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319308059

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http://www.sciencedirect.com/science/article/pii/S1347861319308059

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