Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase inhibitors that grouped into 59 structural cluster...

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Bibliographic Details
Main Authors: Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC6383948?pdf=render

Internet

http://europepmc.org/articles/PMC6383948?pdf=render

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