Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.

Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.

Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as ligand traps. We identified two mutations (N445K,T) in patients with multiple syno...

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Bibliographic Details
Main Authors: Petra Seemann, Anja Brehm, Jana König, Carsten Reissner, Sigmar Stricker, Pia Kuss, Julia Haupt, Stephanie Renninger, Joachim Nickel, Walter Sebald, Jay C Groppe, Frank Plöger, Jens Pohl, Mareen Schmidt-von Kegler, Maria Walther, Ingmar Gassner, Cristina Rusu, Andreas R Janecke, Katarina Dathe, Stefan Mundlos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2776984?pdf=render

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http://europepmc.org/articles/PMC2776984?pdf=render

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