Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells

Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells

A relatively high affinity/avidity of T cell receptor (TCR) recognition for self-peptide bound to major histocompatibility complex II (self-pMHC) ligands is a distinctive feature of CD4 T regulatory (Treg) cells, including their development in the thymus and maintenance of their suppressive function...

Full description

Bibliographic Details
Main Authors: Jun Young Lee, Juhee Kim, Jaeu Yi, Daeun Kim, Hee-Ok Kim, Daehee Han, Jonathan Sprent, You Jeong Lee, Charles D. Surh, Jae-Ho Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
Ly6C
naive CD4 T regulatory cells
effector CD4 T regulatory
conventional effector T cells
T cell receptor
self-peptide/major histocompatibility complex ligands
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00437/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00437/full

Similar Items