Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19

Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19

Summary: Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to complement clinical trials of therapeutic targeting of...

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Bibliographic Details
Main Authors: Lucy C.K. Bell, Cem Meydan, Jacob Kim, Jonathan Foox, Daniel Butler, Christopher E. Mason, Sagi D. Shapira, Mahdad Noursadeghi, Gabriele Pollara
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Immunology
Virology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310932

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220310932

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