Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

In the present work, we explored if Coca-Cola<sup>®</sup> had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin<sup>®</sup>, immediate-release formulation, 10 mg, generic drug product). To map the contribution of underlying physiologica...

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Bibliographic Details
Main Authors: Bart Hens, Marival Bermejo, Rodrigo Cristofoletti, Gregory E. Amidon, Gordon L. Amidon
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
biopharmaceutics classification system (BCS), low aqueous solubility
oral bioavailability
oral drug absorption
in silico modeling
biopredictive dissolution testing
physiologically-based biopharmaceutics modeling (PBBM)
Online Access:https://www.mdpi.com/1999-4923/12/6/566

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https://www.mdpi.com/1999-4923/12/6/566

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