Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. In cold-blooded vertebrates, computational CGI predictions often reside away from gene promoters, suggesting...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/00348 |