Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. In cold-blooded vertebrates, computational CGI predictions often reside away from gene promoters, suggesting...

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Bibliographic Details
Main Authors: Hannah K Long, David Sims, Andreas Heger, Neil P Blackledge, Claudia Kutter, Megan L Wright, Frank Grützner, Duncan T Odom, Roger Patient, Chris P Ponting, Robert J Klose
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-02-01
Series:eLife
Subjects:
CpG island
DNA methylation
epigenetic
Chromatin
Evolutionary conservation
Online Access:https://elifesciences.org/articles/00348

Internet

https://elifesciences.org/articles/00348

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