Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD.

Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD.

IL-17A and IL-17F cytokines are important regulators of acute graft-versus-host-disease (GVHD). However, contrary effects of these cytokines in inflammatory diseases have been reported. To investigate the effects of donor-derived IL-17A and IL-17F on GVHD, we made use of single (Il17a-/- or Il17f-/-...

Full description

Bibliographic Details
Main Authors: Ivan Odak, Alina Depkat-Jakob, Maleen Beck, Michael Jarek, Yan Yu, Ursula Seidler, Sascha David, Arnold Ganser, Reinhold Förster, Immo Prinz, Christian Koenecke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0231222

Internet

https://doi.org/10.1371/journal.pone.0231222

Similar Items