Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

Although Notch signaling has been proposed as a therapeutic target for type-2 diabetes, liver steatosis, and atherosclerosis, its direct effect on pancreatic islets remains unknown. Here, we demonstrated a function of Dll4-Notch signaling inhibition on the biology of insulin-producing cells. We conf...

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Bibliographic Details
Main Authors: Fabienne Billiard, Sevasti Karaliota, Bei Wang, Dimitrios Stellas, Ioannis Serafimidis, Antigoni Manousopoulou, Yiassemi Koutmani, Elpiniki Ninou, Jacquelynn Golubov, Amanda DaNave, Panagiotis Tsakanikas, Yurong Xin, Wen Zhang, Matthew Sleeman, George D. Yancopoulos, Andrew J. Murphy, Spiros D. Garbis, Katia Karalis, Dimitris Skokos
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
notch pathway
delta-like ligand
β-cells
insulin secretion
differentiation
proliferation
diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319137

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http://www.sciencedirect.com/science/article/pii/S2211124717319137

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