Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype

Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype

ObjectiveThere is a critical need to establish genetic markers that explain the complex phenotypes and pathogenicity of ALS. This study identified a polymorphism in the Stathmin-2 gene and investigated its association with sporadic ALS (sALS) disease risk, age-of onset and survival duration.MethodsT...

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Bibliographic Details
Main Authors: Frances Theunissen, Ryan S. Anderton, Frank L. Mastaglia, Loren L. Flynn, Samantha J. Winter, Ian James, Richard Bedlack, Stuart Hodgetts, Sue Fletcher, Steve D. Wilton, Nigel G. Laing, Mandi MacShane, Merrilee Needham, Ann Saunders, Alan Mackay-Sim, Ze’ev Melamed, John Ravits, Don W. Cleveland, P. Anthony Akkari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyotrophic lateral sclerosis
genetic variant
genetic association studies
stathmin-2
genetic marker
structural variation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.658226/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.658226/full

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