Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples

Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples

Archival tumor samples represent a rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the retrospective setting, making it difficult to distin...

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Bibliographic Details
Main Authors: Rebecca F. Halperin, Winnie S. Liang, Sidharth Kulkarni, Erica E. Tassone, Jonathan Adkins, Daniel Enriquez, Nhan L. Tran, Nicole C. Hank, James Newell, Chinnappa Kodira, Ronald Korn, Michael E. Berens, Seungchan Kim, Sara A. Byron
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Oncology
Subjects:
cancer genomics
somatic variant calling
next generation sequencing
tumor-only sequencing
tumor exome sequencing
cancer hotspot mutations
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00119/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00119/full

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