Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques.

Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques.

BACKGROUND: Targeting antigens encoded by DNA vaccines to dendritic cells (DCs) in the presence of adjuvants enhances their immunogenicity and efficacy in mice. METHODOLOGY/PRINCIPAL FINDINGS: To explore the immunogenicity of this approach in non-human primates, we generated a single chain antibody...

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Bibliographic Details
Main Authors: Matthias Tenbusch, Ralf Ignatius, Godwin Nchinda, Christine Trumpfheller, Andres M Salazar, Katharina Töpfer, Ulrike Sauermann, Ralf Wagner, Drew Hannaman, Klara Tenner-Racz, Paul Racz, Christiane Stahl-Hennig, Klaus Uberla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3373620?pdf=render

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http://europepmc.org/articles/PMC3373620?pdf=render

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