Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t<sup>6</sup>A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm<sup>5</sup>s<sup>2</sup>U34) are criti...

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Bibliographic Details
Main Authors: Leticia Pollo-Oliveira, Roland Klassen, Nick Davis, Akif Ciftci, Jo Marie Bacusmo, Maria Martinelli, Michael S. DeMott, Thomas J. Begley, Peter C. Dedon, Raffael Schaffrath, Valérie de Crécy-Lagard
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
trna modification
protein aggregation
Online Access:https://www.mdpi.com/2218-273X/10/2/322

Internet

https://www.mdpi.com/2218-273X/10/2/322

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