Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease

Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease

Neurodegenerative disorders progress across the brain in characteristic spatio-temporal patterns. A better understanding of the factors underlying the specific cell and tissue vulnerability responsible for such patterns could help identify the molecular origins of these conditions. To investigate th...

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Bibliographic Details
Main Authors: Rosie Freer, Pietro Sormanni, Prajwal Ciryam, Burkhard Rammner, Silvio O. Rizzoli, Christopher M. Dobson, Michele Vendruscolo
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Heliyon
Subjects:
Biophysics
Neuroscience
Alzheimer's ​disease
Protein supersaturation
Neuronal vulnerability
Protein homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019362498

Internet

http://www.sciencedirect.com/science/article/pii/S2405844019362498

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