The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

Abstract Background Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs to the cancer cells using ADCs specific for tumor-associated antigens enables sparing the healthy cells and thereby redu...

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Bibliographic Details
Main Authors: Marta Poźniak, Natalia Porębska, Mateusz Adam Krzyścik, Aleksandra Sokołowska-Wędzina, Kamil Jastrzębski, Martyna Sochacka, Jakub Szymczyk, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Medicine
Subjects:
FGFR
ADC
Conjugate
Cytotoxic
Cancer
Online Access:https://doi.org/10.1186/s10020-021-00306-2

Internet

https://doi.org/10.1186/s10020-021-00306-2

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